 Biographical Information
| Fadi Khasawneh - Assistant Professor of Pharmaceutical Sciences |
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Degree
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Year
obtained
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Institution
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Ph.D.
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2007
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University of Illinois at Chicago
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B. Pharm
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1999
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Jordan University of Science and Technology
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Description of Academic/Research Interests:
My research is focused on the study of thrombosis and platelet biology. One of our goals is to delineate signaling pathways involved in human/mouse platelet activation (e.g., aggregation, shape change, and secretion), and to investigate their role in the pathogenesis of thrombotic diseases. Another goal is to map the G-protein coupling domains of certain platelet G-protein coupled receptors. We will employ a host of molecular, biochemical and pharmacological approaches, as well as an in vivo Carotid Artery Thrombosis model in our studies. Our ultimate goal is to identify novel therapeutic targets for the management of thromboembolic disorders.
| Selected Publications |
| Khasawneh, F.T., Huang, J., Turek, J., and Le Breton, G.C., "Differential Mapping of the Amino Acids Mediating Agonist and Antagonist Coordination with the Human Thromboxane A2 Receptor Protein," J. Biol. Chem., Vol. 281 (37), 26951-26965, 2006. |
| Khasawneh, F.T., Huang, J., Mir, F., Srinivasan, S., Tiruppathi, C., and Le Breton, G.C., "Characterization of isoprostane signaling: Evidence for a unique coordination profile of 8-iso-PGF2? with the thromboxane A2 receptor, and activation of a separate cAMP-dependent inhibitory pathway in human platelets," In Press, Biochemical Pharmacology. |
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Contact Information
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Office address: 309 E. Second St.
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Pomona, CA 91766
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Main phone: (909) 469-5500
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Fax: (909) 469-5600
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E-mail: fkhasawneh@westernu.edu
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© 2008 Western University of Health Sciences. All Rights Reserved | 309 E. Second St. Pomona, CA 91766-1854 | (909) 623-6116 